Some people have touted herbal medications such as St. John's Wort (used as an antidepressant) and kava kava (used to relieve anxiety) as substitutes for approved smoking cessation medications. These herbal remedies have no proven benefit in helping smokers quit and may have harmful side effects.(38) Since herbal remedies interact with some prescription and over-the-counter drugs, anyone who is taking any kind of medication -- including medications used in smoking cessation -- should not take herbal remedies without consulting a physician.